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In March 2024, FDA approved a new indication to reduce MACE in adults with established CV disease and overweight/obesity based on SELECT, marking the first obesity medication with a dedicated CV riskreduction label in this population

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Quality independent variables such as sex were also included as per cohort standards

Beyond this window, degradation accelerates even under refrigeration

CMS , Interoperability and Prior Authorization Final Rule (CMS-0057-F) (Jan 2026) FHIR API mandates and PA timeline reforms ( [16] )

Other known interactions include barbiturates, fosphenytoin (Cerebyx, Sesquient), phenytoin (Dilantin, Phenytek), and Levodopa